Boris Johnson has said people in the UK should avoid "non-essential" travel and contact with others to curb coronavirus.
The prime minister said people should work from home where possible as part of a range of stringent new measures.
Pregnant women, people over the age of 70 and those with certain health conditions should consider the advice "particularly important", he said.
People in at-risk groups will be asked within days to stay home for 12 weeks.
Health Secretary Matt Hancock told the House of Commons "the disease is now accelerating".
In the first of a series of daily briefings on the virus, which causes the Covid-19 disease, Mr Johnson said "drastic action" was needed as the UK approaches "the fast growth part of the upward curve" in the number of cases.
Mr Johnson said that by next weekend, those with the most serious health conditions must be "largely shielded from social contact for around 12 weeks".
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The prime minister will host Monday's press conference with UK chief medical adviser, Prof Chris Whitty, and Sir Patrick Vallance, the UK's chief scientific adviser
Boris Johnson will outline the next steps in the UK's plan to fight coronavirus at the first of a series of daily news conferences.
The briefing will follow a Cobra meeting which is expected to look at what steps the government could take to protect elderly and vulnerable people.
The over-70s have been told they are allowed to go out for walks when their period of staying at home begins.
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