Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end.
They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work.
Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage.
Timestamps
00:00 Introduction
03:42 Building tools to accelerate scientific discovery
05:26 The credible path to funding basic science
07:03 Biohub = Frontier Biology + Frontier AI
08:58 Challenges building on a 10-15 year timeline
09:39 How CZI chooses what to work on
11:17 Making sense of science with LLMs
11:32 Measuring success in the therapeutic realm
13:32 "Most diseases should be thought of as rare diseases”
15:39 Inspiration: building a periodic table for biology
19:27 Why virtual cells?
21:17 The Biohub Master Plan
21:51 How virtual cell models allow more risk taking
28:15 Bringing CZI & Biohub together
30:32 Why Biohub matters
33:36 The importance of interface design in democratizing scientific discovery
35:34 How Biohub encourages cross-functional collaboration
40:38 Looking ahead: the broader impact of AI on biotech
