OpenEvidence Inc., medtech, Cambridge, Massachusetts, USA


The AI Product Going Viral With Doctors: OpenEvidence, with CEO Daniel Nadler

Mar 4, 2025

OpenEvidence is transforming how doctors access medical knowledge at the point of care, from the biggest medical establishments to small practices serving rural communities. Founder Daniel Nadler explains his team’s insight that training smaller, specialized AI models on peer-reviewed literature outperforms large general models for medical applications. He discusses how making the platform freely available to all physicians led to widespread organic adoption and strategic partnerships with publishers like the New England Journal of Medicine. In an industry where organizations move glacially, 10-20% of all U.S. doctors began using OpenEvidence overnight to find information buried deep in the long tail of new medical studies, to validate edge cases and improve diagnoses. Nadler emphasizes the importance of accuracy and transparency in AI healthcare applications.

00:00 - Introduction
02:05 - Doctors are consumers
08:40 - The firehose of medical knowledge
18:08 - What is the evidence?
24:57 - What does “open” mean?
31:41 - How’d you build it?
38:18 - What about hallucinations?
45:34 - What’s changed about starting an AI company?
49:17 - Hire for neuroplasticity
55:33 - Lightning Round
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